Neuroscience of OCD by Kelly Jean Sullivan

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What is the neuroscience behind OCD?

OCD has typically been associated with grey matter volume increases in sub-cortical structures (such as the putamen and globus pallidus), and with grey matter reductions in the cortex especially ventral and dorsal medial cortex, and inferior frontal cortex.

What part of the brain is damaged in OCD?

Imaging, surgical, and lesion studies suggest that the prefrontal cortex (orbitofrontal and anterior cingulate cortexes), basal ganglia, and thalamus are involved in the pathogenesis of obsessive-compulsive disorder (OCD